Myocardial Infarction Genetic Database

Gene information

Official symbol	LTA4H
Official full name	leukotriene A4 hydrolase
Gene type	protein-coding gene
Chromosome	12q23.1
Gene family	M1 metallopeptidases
Resources
Entrez Gene	4048
HGNC	HGNC:6710
Ensembl	ENSG00000111144
Vega	OTTHUMG00000170355
UCSC	uc001ten.3

GO terms: 20 records

GO	Description	Category	LogP	Number of genes	Detail
GO:0006518	peptide metabolic process	GO Biological Processes	-2.74792434	15	More
GO:0006690	icosanoid metabolic process	GO Biological Processes	-21.0788451	23	More
GO:0006691	leukotriene metabolic process	GO Biological Processes	-6.89692596	7	More
GO:0008235	metalloexopeptidase activity	GO Molecular Functions	-2.10458444	4	More
GO:0009725	response to hormone	GO Biological Processes	-49.1091700	138	More
GO:0010035	response to inorganic substance	GO Biological Processes	-29.1720710	89	More
GO:0010038	response to metal ion	GO Biological Processes	-20.5090881	61	More
GO:0010043	response to zinc ion	GO Biological Processes	-4.20672176	10	More
GO:0016053	organic acid biosynthetic process	GO Biological Processes	-15.6178787	26	More
GO:0019370	leukotriene biosynthetic process	GO Biological Processes	-4.00389964	4	More
GO:0030323	respiratory tube development	GO Biological Processes	-8.11012280	27	More
GO:0030324	lung development	GO Biological Processes	-8.32855168	27	More
GO:0030855	epithelial cell differentiation	GO Biological Processes	-14.2408795	69	More
GO:0043434	response to peptide hormone	GO Biological Processes	-26.1739008	69	More
GO:0043603	cellular amide metabolic process	GO Biological Processes	-1.84597279	17	More
GO:0044283	small molecule biosynthetic process	GO Biological Processes	-16.6163676	33	More
GO:0046394	carboxylic acid biosynthetic process	GO Biological Processes	-15.6974044	26	More
GO:0046456	icosanoid biosynthetic process	GO Biological Processes	-13.7551761	13	More
GO:0060541	respiratory system development	GO Biological Processes	-8.30305934	29	More
GO:1901652	response to peptide	GO Biological Processes	-34.9047734	89	More

KEGG pathways: 1 record

KEGG	Description	Category	LogP	Number of genes	Detail
hsa00590	Arachidonic acid metabolism	KEGG Pathway	-11.1782370	12	More

Drug-Gene interaction

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Related drugs: 8 records

Drug name	Source	PMID	View
acebilustat	TTD		view
albumin human	NCI	1314659	view
chembl224318	DTC	18952425	view
chembl398021	DTC	18952425	view
chembl444161	DTC	18952425	view
chembl455078	DTC	18952425	view
diphenylether	DTC	18952425	view
montelukast	PharmGKB		view

Related studies: 3 records

Molecular factor	Omics type	Objective	MI type	Reference
NC_000012.12:g.[SG12S16A>G;96007474G>A;96009832T>C;96015423A>G; 96020673T>C;96028599T>C;96032219T>G;96041102C>T;96044775G>A;96047515G>A]	genomics	myocardial infarction[diagnosis]	myocardial infarction	Helgadottir A et al. Nat Genet. 2006
NM_000895.3:c.290+456A>G	genomics	myocardial infarction[diagnosis]	myocardial infarction	Gammelmark A et al. PLoS One. 2016
NM_000895.3:c.88-6820C>T	genomics	myocardial infarction[diagnosis]	myocardial infarction	Li Y et al. Lipids Health Dis. 2019